ea0037gp.28.07 | Endocrine tumours and neoplasia – NETS | ECE2015
Tresoldi Alberto Stefano
, Bonifacio Cristina
, Pepe Giovanna
, Carnaghi Carlo
, Lania Andrea Gerardo Antonio
Gastric carcinoids secondary to autoimmune atrophic gastritis (GC type 1) are usually well differentiated neoplasia, with an indolent course and an excellent overall prognosis. However, a subset of these tumors (<5%) may develop advanced disease, with lymph node and/or hepatic metastasis. The pathogenesis of these carcinoids is related to chronic trophic stimuli to enterochromaffin-like (ECL) cells due to chronic hypergastrinemia. Treatments directed to remove the source o...